Origin supports formula for tick labels.

If it’s used and then user adds data label, annotation, and some gadgets to show X, Y value, user can set Custom Format as X, Y, Z to show value based on tick label formula.

For Data Label, when picking Y as Label Form, set Custom Format as Y, Y, .2, Y, *4 to set decimal places and significant digits.

For data annotation, set label form as $(Y, Y), $(Y, Y, .2), $(Y, Y, *4)

This also applies to Vertical Cursor and Quick Peak gadgets.