This is a German only crash in Origin 2022.

Fixed in Orign2022b.

Choose Preferences: Options menu.

Go to Graph tab.

Mouse over the big User-defined Symbols box.

==> Crash.

Workaround: Set Help: Change Language to change Origin to English to create user-defined symbols. Then switch language back to German to use the created symbols.

Or copy image to clipboard and choose the user-defined symbol on clipboard in Plot Details dialog.

As long as you don’t mouse over the control in Options dialog in German Origin, it’s fine.